| A Short Health Care Industry Glossary | i |
| Introduction | 1 |
| How to Use This Book | 3 |
| Chapter 1: Major Trends Affecting the Health Care Industry | 7 |
| 1) Introduction to the Health Care Industry | 7 |
| 2) Continued Rise in Health Care Costs | 10 |
| 3) Employers Push Health Care Costs onto Employees/On-Site Clinics Begin to Appear | 10 |
| 4) Medicare and Medicaid Spending Continue to Surge/Oldest Baby Boomers Hit 65+ Years of Age | 11 |
| 5) Health Care Reform Act of 2010 Set to Bring Big Changes | 12 |
| 6) Insurance Companies Change Strategies Due to Health Care Reform Act | 13 |
| 7) Vast Number of Uninsured and Underinsured Americans | 14 |
| 8) Few New Blockbusters: Major Drug Patents Expire While Generic Sales Growth Continues | 14 |
| 9) Biotech and Orphan Drugs Pick Up the Slack as Blockbuster Mainstream Drugs Age | 16 |
| 10) Quality of Care and Health Care Outcomes Data Become Available Online | 17 |
| 11) Malpractice Suits Are Blamed for Rising Health Care Costs/Tort Reform Is Capping Awards for Damages | 18 |
| 12) Transplants Are Big Business | 19 |
| 13) Obesity Sparks Government Action | 19 |
| 14) Health Care Goes Offshore, Medical Tourism and Clinical Trials Thrive in China, India and Elsewhere | 21 |
| 15) Disease Management Programs Take Root | 23 |
| 16) Clinics Open in Retail Store Settings and Employer Sites | 23 |
| 17) Health Care Industry Grows Rapidly in China and India | 24 |
| The Outlook for Health Care Technology: | 25 |
| 18) Health Care Technology Introduction | 25 |
| 19) Health Information Research Remains a Leading Use of the Internet | 26 |
| 20) RFID Will Manage Hospital and Pharmacy Inventories | 27 |
| 21) Electronic Health Records (EHR) Digitize Patient Records at an Accelerating Pace | 27 |
| 22) Remote Patient Monitoring Advances through Wireless Systems | 29 |
| 23) Stem Cells—Multiple Sources Stem from New Technologies | 30 |
| 24) Government Support for Stem Cell Research Evolves | 31 |
| 25) Stem Cells—Therapeutic Cloning Techniques Advance | 32 |
| 26) Stem Cells—A New Era of Regenerative Medicine Takes Shape | 33 |
| 27) Gene Therapies and Patients’ Genetic Profiles Promise a Personalized Approach to Medicine | 35 |
| 28) Breakthrough New Drug Delivery Systems Evolve | 37 |
| 29) Advances in Cancer Research and Therapies | 38 |
| 30) Proton Beams—The Ultimate Radiation Therapy | 39 |
| 31) Better Imaging, including MRI, PET and 320-Slice CT, Creates Advances in Detection | 40 |
| 32) Molecular Imaging will Lead to Early Detection and Early Cure of Cancerous Tumors | 42 |
| 33) Advances in Laboratory Testing | 43 |
| 34) Advances in Surgery | 44 |
| 35) Other Treatment Technologies | 46 |
| 36) Nanotechnology Makes Breakthroughs in Health Care | 49 |
| Chapter 2: Health Care Industry Statistics | 51 |
| I. U.S. Health Care Industry Overview | 52 |
| U.S. Health Care Industry Overview | 53 |
| Global Health Statistics | 54 |
| Affordable Care Act Overview | 55 |
| Domestic & Foreign Pharmaceutical Sales, PhRMA Member Companies: 1975-2010 | 57 |
| Employment in the Health Care Industry, U.S.: 2005-2010 | 58 |
| Employment & Earnings in Health Care Practitioner & Technical Occupations, U.S.: May 2010 | 60 |
| Employment & Earnings in Health Care Support Occupations, U.S.: May 2010 | 61 |
| Federal R&D & R&D Plant Funding for National Institutes of Health, U.S.: Fiscal Years 2009-2011 | 62 |
| The U.S. Drug Discovery & Approval Process | 63 |
| U.S. FDA New Drug (NDA) and Biologic (BLA) Approvals, 2010 | 64 |
| II. U.S. Health Care Expenditures & Costs | 65 |
| The Nation's Health Dollar: 2012 Where It Came From (Estimated) | 66 |
| The Nation's Health Dollar: 2012 Where It Went (Estimated) | 67 |
| National Health Expenditures & Average Annual Percent Change: Selected Calendar Years, 2005-2020 | 68 |
| National Health Expenditures by Type of Expenditure with Affordable Care Act Impacts: Selected Calendar Years, 2005-2020 | 69 |
| National Health Expenditures by Type of Expenditure without Affordable Care Act Impacts: Selected Calendar Years, 2005-2020 | 70 |
| Hospital Care Expenditures & Average Annual Percent Change, U.S.: Selected Calendar Years, 2005-2020 | 71 |
| Hospital Care Expenditures, Percent Distribution & Per Capita Amount, U.S.: Selected Calendar Years, 2005-2020 | 72 |
| Nursing Home Care Expenditures & Average Annual Percent Change, U.S.: Selected Calendar Years, 2005-2020 | 73 |
| Nursing Home Care Expenditures, Percent Distribution & Per Capita Amount: Selected Calendar Years, 2005-2020 | 74 |
| Home Health Care Expenditures and Average Annual Percent Change, U.S.: Selected Calendar Years, 2005-2020 | 75 |
| Home Health Care Expenditures, Percent Distribution & Per Capita Amounts, U.S.: Selected Calendar Years, 2005-2020 | 76 |
| Prescription Drug Expenditures, U.S.: 1965-2020 | 77 |
| U.S. Prescription Drug Expenditures & Average Annual Percent Change: Selected Calendar Years 2005-2020 | 79 |
| U.S. Prescription Drug Expenditures, Percent Distribution & Per Capita Amount: Selected Calendar Years, 2005-2020 | 80 |
| III. Medicare & Medicaid | 81 |
| Medical Care Benefits in the U.S.: Access, Participation and Take-Up Rates, March 2011 | 82 |
| Medicare Enrollment, 1970-2085 | 83 |
| Medicare Cost & Non-Interest Income by Source as a Percent of GDP, 1967-2081 | 84 |
| Medicare Part D Enrollment, 2010 | 85 |
| Medicare Beneficiaries with Prescription Drug Coverage, Summary Report: July 2011 | 86 |
| IV. U.S. Health Insurance Coverage & The Uninsured | 87 |
| Number & Percent of Persons of All Ages with and without Health Insurance Coverage, U.S.: 1999-2010 | 88 |
| Number & Percent of Persons of All Ages without Health Insurance Coverage, by Race/Ethnicity, U.S.: 2002-2010 | 89 |
| Number & Percent of Persons without Health Insurance Coverage, by Age Group, U.S.: 1999-2010 | 90 |
| Number & Percent of Persons without Health Insurance Coverage, by Age Group & Sex: U.S.: 2010 | 91 |
| Employers' Costs for Health Insurance, Amount & Percent of Total Compensation, U.S.: Selected Years, 2006-2010 | 92 |
| V. U.S. Vital Statistics & Population Indicators | 93 |
| Life Expectancy at Age 65, U.S., Selected Years | 94 |
| Current Cigarette Smoking by Persons 18 Years of Age & Over: Selected Years, 1997-2010 | 95 |
| Current Cigarette Smoking by Age Group and Sex, 2010 | 96 |
| Overweight & Obesity Among Persons 20 Years of Age & Over, According to Sex, Race & Hispanic Origin: Selected Years, 1960-2008 | 97 |
| Chapter 3: Important Health Care Industry Contacts | 99 |
| (Addresses, Phone Numbers and Internet Sites) | |
| Chapter 4: THE HEALTH CARE 500: | |
| Who They Are and How They Were Chosen | 143 |
| Industry List, With Codes | 144 |
| Index of Companies Within Industry Groups | 146 |
| Alphabetical Index | 158 |
| Index of U.S. Headquarters Location by State | 161 |
| Index of Non-U.S. Headquarters Location by Country | 164 |
| Index by Regions of the U.S. Where the Firms Have Locations | 165 |
| Index by Firms with International Operations | 174 |
| Individual Data Profiles on Each of THE HEALTH CARE 500 | 177 |
| Additional Indexes | |
| Index of Hot Spots for Advancement for Women/Minorities | 656 |
| Index by Subsidiaries, Brand Names and Selected Affiliations | 658 |